The Unresolved Snapshot

Addressing the Unresolved Issues

The landscape of early breast cancer has changed dramatically with significant advancements in early screening and diagnosis and curative-intent therapies. Indeed, breast cancer–specific survival has improved by 20% during the past 30 years, and 5-year survival is now 98% for early-stage disease.1 As a consequence, the risk and nature of adjuvant therapy–induced immediate and late-occurring car...

The Novel Coronavirus – A Snapshot of Current Knowledge

Another animal to human transmission of a coronavirus occurred in December 2019 on a live animal market in the Chinese city of Wuhan causing an epidemic in China, reaching now different continents. This minireview summarizes the research literature on the virological, clinical and epidemiological aspects of this epidemic published until end of February 2020.

Unresolved challenges

This workshop was the third of a series on the health transition sponsored by the Rockefeller Foundation. The first, in Canberra, addressed the question: ‘What is the health transition?’ The second, in London, asked: ‘How does one go about studying the health transition?’. This third and final workshop posed the challenge: ‘How does social science research relate to health policy and action?’. ...

SnapShot: The ESCRT Machinery

Fistula Treatment: The Unresolved Challenge

In population-based studies, up to 50% of patients with Crohn's disease suffer from fistulas. Fistulas pose a considerable morbidity including permanent sphincter and perineal tissue destruction as well as professional and personal disabilities. Treatment options have progressed in recent years and fistula closure and fibrosis of the fistula track is achieved in some patients. Depending on seve...